Transcutaneous electrical nerve stimulation for fibromyalgia-like syndrome in patients with Long-COVID: a pilot randomized clinical trial

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  • Raveendran, A., Jayadevan, R. & Sashidharan, S. Long COVID: an overview. Diabetes Metab. Syndr. Clin. Res. Revi. 15, 869–875 (2021).

    Article 
    CAS 

    Google Scholar 

  • Control, C. D. & Prevention Nearly one in five American adults who have had COVID-19 still have long COVID. Natl. Center Health Stat. 622 (2022).

  • Sojka, A., Machniak, M., Andrzejewski, W., Kosendiak, A. & Chwałczyńska, A. Changes in physical activity and the occurrence of specific symptoms of long-COVID syndrome in men aged 18–25. Int. J. Environ. Res. Public Health 19, 1199 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Khoja, O. et al. Clinical characteristics and mechanisms of musculoskeletal pain in long COVID. J. Pain Res. 1729–1748 (2022).

  • Parker, A. M. et al. Addressing the post-acute sequelae of SARS-CoV-2 infection: a multidisciplinary model of care. Lancet Respir. Med. 9, 1328–1341 (2021).

    Article 
    CAS 

    Google Scholar 

  • Keklicek, H., Selçuk, H., Kurt, İ., Ulukaya, S. & Öztürk, G. Individuals with a COVID-19 history exhibit asymmetric gait patterns despite full recovery. J. Biomech. 137, 111098 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mitrović-Ajtić, O. et al. in Healthcare. (MDPI) (1666).

  • Gil, S. et al. Post-acute sequelae of SARS-CoV-2 associates with physical inactivity in a cohort of COVID-19 survivors. Sci. Rep. 13, 215. (2023).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Burgmer, M. et al. Cerebral mechanisms of experimental hyperalgesia in fibromyalgia. Eur. J. Pain 16, 636–647 (2012).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Suchdev, P. et al. Overview of the biomarkers reflecting inflammation and nutritional determinants of Anemia (BRINDA) project. Adv. Nutr. 7, 349–356 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Control, C., f., D. & Prevention post-COVID conditions: Information for healthcare providers. (2024).

  • Plaut, S. & Long COVID-19 and viral fibromyalgia-ness: suggesting a mechanistic role for fascial myofibroblasts (Nineveh, the shadow is in the fascia). Front. Med. 10, 952278 (2023).

    Article 

    Google Scholar 

  • Ursini, F. et al. Fibromyalgia: a new facet of the post-COVID-19 syndrome spectrum? Results from a web-based survey. RMD Open 7, e001735 (2021).

    Article 
    PubMed 

    Google Scholar 

  • Cordero, M. D. The inflammasome in fibromyalgia and CRPS: a microglial hypothesis? Nat. Rev. Rheumatol. 11, 630–630 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • O’Brien, A. T., Deitos, A., Pego, Y. T. & Fregni, F. Carrillo-de-la-Peña, M. T. Defective endogenous pain modulation in fibromyalgia: a meta-analysis of temporal summation and conditioned pain modulation paradigms. J. Pain 19, 819–836 (2018).

    Article 
    PubMed 

    Google Scholar 

  • Williams, D. A. & Gracely, R. H. Biology and therapy of fibromyalgia. Functional magnetic resonance imaging findings in fibromyalgia. Arthritis Res. Ther. 8, 1–8 (2007).

    Google Scholar 

  • Clough, E. et al. Mitochondrial dynamics in SARS-COV2 spike protein treated human microglia: implications for neuro-COVID. J. Neuroimmune Pharmacol., 1–15 (2021).

  • Li, S. et al. SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation. Signal. Transduct. Target. Ther. 5, 235 (2020).

    Article 
    CAS 

    Google Scholar 

  • Panariello, F., Cellini, L., Speciani, M., De Ronchi, D. & Atti, A. R. How does SARS-CoV-2 affect the central nervous system? A working hypothesis. Front. Psychiatr. 11, 582345 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Atta, A. A., Ibrahim, W. W., Mohamed, A. F. & Abdelkader N. F. Microglia polarization in nociplastic pain: mechanisms and perspectives. Inflammopharmacology 31, 1053–1067 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Berry, M. et al. Dynamic functional brain connectivity underlying temporal summation of pain in fibromyalgia. Arthritis Rheumatol. 74, 700–710 (2022).

    Article 
    PubMed 

    Google Scholar 

  • Mosch, B., Hagena, V., Herpertz, S. & Diers, M. Brain morphometric changes in fibromyalgia and the impact of psychometric and clinical factors: a volumetric and diffusion-tensor imaging study. Arthritis Res. Ther. 25, 81 (2023).

    Article 

    Google Scholar 

  • Scardua-Silva, L. et al. Microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19. Sci. Rep. 14, 1758 (2024).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fialho, M. F. P., Brum, E. S. & Oliveira, S. M. Could the fibromyalgia syndrome be triggered or enhanced by COVID-19? Inflammopharmacology 31, 633–651 (2023).

  • A Phase 2 study to evaluate the efficacy and safety of TNX-102 SL in patients with Multi-site Pain Associated with Post-acute Sequelae of SARS-CoV-2 (2023). Infection (PREVAIL).

  • Fernández-de‐las‐Peñas, C., Nijs, J., Giordano, R. & Arendt‐Nielsen, L. Precision management of post‐COVID pain: an evidence and clinical‐based approach. Eur. J. Pain 27, 1107–1125 (2023).

    Article 
    PubMed 

    Google Scholar 

  • DeSantana, J. M., Walsh, D. M., Vance, C., Rakel, B. A. & Sluka, K. A. Effectiveness of transcutaneous electrical nerve stimulation for treatment of hyperalgesia and pain. Curr. Rheumatol. Rep. 10, 492–499 (2008).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Vance, C. G., Dailey, D. L., Rakel, B. A. & Sluka, K. A. using TENS for pain control: the state of the evidence. Pain Manag. 4, 197–209 (2014).

    Article 

    Google Scholar 

  • Gozani, S. N. Remote analgesic effects of conventional transcutaneous electrical nerve stimulation: a scientific and clinical review with a focus on chronic pain. J. pain Res., 3185–3201 (2019).

  • Lin, T., Gargya, A., Singh, H., Sivanesan, E. & Gulati, A. Mechanism of peripheral nerve stimulation in chronic pain. Pain Med. 21, S6–S12 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Moayedi, M. & Davis, K. D. Theories of pain: from specificity to gate control. J. Neurophysiol. (2013).

  • Amer-Cuenca, J. J. et al. The dose-dependent effects of transcutaneous electrical nerve stimulation for pain relief in individuals with fibromyalgia: a systematic review and meta-analysis. Pain 10.1097 (2022).

  • Johnson, M. I., Claydon, L. S., Herbison, G. P., Jones, G. & Paley, C. A. Transcutaneous electrical nerve stimulation (TENS) for fibromyalgia in adults. Cochrane Database Syst. Rev. 10, Cd012172. (2017).

    Article 
    PubMed 

    Google Scholar 

  • Quell 2.0. Wearable pain relief technology TM User Manual. (2018).

  • Jamison, R. N. et al. Effects of wearable transcutaneous electrical nerve stimulation on fibromyalgia: a randomized controlled trial. J. Pain Res. 2265–2282 (2021).

  • Cleeland, C. & Ryan, K. Pain assessment: global use of the brief Pain Inventory. Ann. Acad. Med. Singapore 23, 129–138 (1994).

    CAS 
    PubMed 

    Google Scholar 

  • Neuberger, G. B. Measures of fatigue: the fatigue questionnaire, fatigue severity scale, multidimensional assessment of fatigue scale, and short Form-36 vitality (Energy/Fatigue) subscale of the short Form Health Survey. Arthr. Rhuem. 49, S175–S183 (2003).

    Article 

    Google Scholar 

  • Merriwether, E. N. et al. Physical activity is related to function and fatigue but not pain in women with fibromyalgia: baseline analyses from the fibromyalgia activity study with TENS (FAST). Arthritis Res. Ther. 20, 199. (2018).

  • Beauchet, O. et al. Walking speed-related changes in stride time variability: effects of decreased speed. J. Neuroeng. Rehabil. 6, 1–6 (2009).

  • Deusen, J. V. Temporal and Distance Parameters, in Assessment in Occupational Therapy and Physical Therapy Chap. 17. (1996).

  • Lee, T., Lee, M., Youm, C., Noh, B. & Park, H. Association between gait variability and gait-ability decline in elderly women with subthreshold insomnia stage. Int. J. Environ. Res. Public Health 17, 5181 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kang, G. E., Zahiri, M., Lepow, B., Saleem, N. & Najafi, B. The effect of daily use of plantar mechanical stimulation through micro-mobile foot compression device installed in shoe insoles on vibration perception, gait, and balance in people with diabetic peripheral neuropathy. J. Diabetes Sci. Technol. 13, 847–856 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Gewandter, J. S. et al. Wireless transcutaneous electrical nerve stimulation (TENS) for chronic chemotherapy-induced peripheral neuropathy (CIPN): a proof-of-concept randomized clinical trial. J. pain (2023).

  • Venkatesh, V. & Davis, F. D. A theoretical extension of the technology acceptance model: four longitudinal field studies. Manag. Sci. 46, 186–204 (2000).

    Article 

    Google Scholar 

  • Jamison, R. N. et al. Effects of wearable transcutaneous electrical nerve stimulation on fibromyalgia: a randomized controlled trial. J. Pain Res. 14, 2265–2282. (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zulbaran-Rojas, A. et al. Optimizing tissue oxygenation in reduction mammoplasty: the role of continuous diffusion of oxygen: a feasibility pilot randomized controlled trial. J. Surg. Res. 292, 113–122 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Zulbaran-Rojas, A., Mishra, R., Pham, A., Suliburk, J. & Najafi, B. Continuous diffusion of oxygen adjunct therapy to improve scar reduction after cervicotomy–A proof of concept randomized controlled trial. J. Surg. Res. 268, 585–594 (2021).

    Article 
    PubMed 

    Google Scholar 

  • Zulbaran-Rojas, A., Park, C., El-Refaei, N., Lepow, B. & Najafi, B. Home-based electrical stimulation to accelerate wound healing—a double-blinded randomized control trial. J. Diabetes Sci. Technol. 17, 15–24 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wolfe, F. et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res. 62, 600–610 (2010).

    Article 

    Google Scholar 

  • Arnold, L. M. et al. A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorder. Pain 119, 5–15 (2005).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Arnold, L. M., Gendreau, R. M., Palmer, R. H., Gendreau, J. F. & Wang, Y. Efficacy and safety of milnacipran 100 mg/day in patients with fibromyalgia: results of a randomized, double-blind, placebo‐controlled trial. Arthr. Rhuem. 62, 2745–2756 (2010).

    Article 
    CAS 

    Google Scholar 

  • Coskun Benlidayi, I. The effectiveness and safety of electrotherapy in the management of fibromyalgia. Rheumatol. Int. 40, 1571–1580 (2020).

    Article 
    PubMed 

    Google Scholar 

  • Salaffi, F., Stancati, A., Silvestri, C. A., Ciapetti, A. & Grassi, W. Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale. Eur. J. Pain 8, 283–291 (2004).

    Article 
    PubMed 

    Google Scholar 

  • Ahmed, M., Aamir, R., Jishi, Z. & Scharf, M. B. The effects of milnacipran on sleep disturbance in fibromyalgia: a randomized, double-blind, placebo-controlled, two-way crossover study. J. Clin. Sleep. Med. 12, 79–86. (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kong, X. & Gozani, S. N. Effectiveness of fixed-site high-frequency transcutaneous electrical nerve stimulation in chronic pain: a large-scale, observational study. J. pain Res. 703–714 (2018).

  • Azadvari, M., Haghparast, A., Nakhostin-Ansari, A., Razavi, S. Z. E. & Hosseini, M. Musculoskeletal symptoms in patients with long COVID: a cross-sectional study on Iranian patients. Heliyon 8 (2022).

  • Bormann, J., Shively, M., Smith, T. L. & Gifford, A. L. Measurement of fatigue in HIV-Positive adults: reliability and validity of the global fatigue index. J. Assoc. Nurses AIDS Care 12, 75–83 (2001).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Stebbings, S., Herbison, P., Doyle, T., Treharne, G. J. & Highton, J. A comparison of fatigue correlates in rheumatoid arthritis and osteoarthritis: disparity in associations with disability, anxiety and sleep disturbance. Rheumatology 49, 361–367 (2009).

    Article 
    ADS 
    PubMed 

    Google Scholar 

  • Straube, S., Derry, S., Moore, R. A. & McQuay, H. J. Pregabalin in fibromyalgia: meta-analysis of efficacy and safety from company clinical trial reports. Rheumatology 49, 706–715 (2010).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Crofford, L. J. et al. Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): a 6-month, double-blind, placebo-controlled trial with pregabalin. Pain 136, 419–431 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Moore, A. R. et al. Fibromyalgia: moderate and substantial pain intensity reduction predicts improvement in other outcomes and substantial quality of life gain. Pain 149, 360–364 (2010).

    Article 
    PubMed 

    Google Scholar 

  • Dailey, D. L. et al. A randomized controlled trial of tens for movement-evoked pain in women with fibromyalgia. Arthritis Rheumatol. (Hoboken NJ) 72, 824 (2020).

    Article 
    CAS 

    Google Scholar 

  • Carrasco-Vega, E., Ruiz-Muñoz, M., Cuesta-Vargas, A., Romero-Galisteo, R. P. & González-Sánchez, M. Individuals with fibromyalgia have a different gait pattern and a reduced walk functional capacity: a systematic review with meta-analysis. PeerJ 10, e12908 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Heredia-Jimenez, J., Latorre-Roman, P., Santos-Campos, M., Orantes-Gonzalez, E. & Soto-Hermoso, V. M. Spatio-temporal gait disorder and gait fatigue index in a six-minute walk test in women with fibromyalgia. Clin. Biomech. Elsevier Ltd. 33, 1–6 (2016).

    Article 

    Google Scholar 

  • Martín-Martínez, J. P. et al. Impact of cognitive tasks on biomechanical and kinematic parameters of gait in women with fibromyalgia: a cross-sectional study. Physiol. Behav. 227, 113171 (2020).

    Article 
    PubMed 

    Google Scholar 

  • Radunović, G. et al. Assessment of gait in patients with fibromyalgia during motor and cognitive dual task walking: a cross-sectional study. Adv. Rheumatol. 61, 53 (2021).

    Article 
    PubMed 

    Google Scholar 

  • Kaleth, A. S., Slaven, J. E. & Ang, D. C. Determining the minimal clinically important difference for 6-minute walk distance in fibromyalgia. Am. J. Phys. Med. Rehabil. 95, 738–745 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Salvat, I. et al. Functional status, physical activity level, and exercise regularity in patients with fibromyalgia after multidisciplinary treatment: retrospective analysis of a randomized controlled trial. Rheumatol. Int. 37, 377–387 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Tiidus, P. M., Pierrynowski, M. & Dawson, K. A. Influence of moderate training on gait and work capacity of fibromyalgia patients: a preliminary field study. J. Sports Sci. Med. 1, 122 (2002).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Tran, S. T. et al. A pilot study of biomechanical assessment before and after an integrative training program for adolescents with juvenile fibromyalgia. Pediatr. Rheumatol. Online J. 14, 43. (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lin, S., Sun, Q., Wang, H. & Xie, G. Influence of transcutaneous electrical nerve stimulation on spasticity, balance, and walking speed in stroke patients: a systematic review and meta-analysis. J. Rehabil. Med. 50, 3–7 (2018).

    Article 
    PubMed 

    Google Scholar 

  • Appelman, B. et al. Muscle abnormalities worsen after post-exertional malaise in long COVID. Nat. Commun. 15, 1–15 (2024).

    Article 

    Google Scholar 

  • Singh, I. et al. Persistent exertional intolerance after COVID-19: insights from invasive cardiopulmonary exercise testing. Chest 161, 54–63 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Roskell, N. S., Beard, S. M., Zhao, Y. & Le, T. K. A meta-analysis of pain response in the treatment of fibromyalgia. Pain Pract. 11, 516–527 (2011).

    Article 
    PubMed 

    Google Scholar 

  • Arnold, L. M. et al. A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder. Arthritis Rheum. Official J. Am. Coll. Rheumatol. 50, 2974–2984 (2004).

    Article 
    CAS 

    Google Scholar 

  • Orfei, M. D. et al. A new look on long-COVID effects: the functional brain fog syndrome. J. Clin. Med. 11, 5529 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Dailey, D. L. et al. Transcutaneous electrical nerve stimulation reduces pain, fatigue and hyperalgesia while restoring central inhibition in primary fibromyalgia. Pain® 154, 2554–2562 (2013).

    Article 
    PubMed 

    Google Scholar 

  • Zulbaran-Rojas, A. et al. Electrical stimulation to regain lower extremity muscle perfusion and endurance in patients with post‐acute sequelae of SARS CoV‐2: a randomized controlled trial. Physiol. Rep. 11, e15636 (2023).

    Article 
    CAS 

    Google Scholar 

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